ACVR2A antibody (C-Term)

Catalog No. ABIN5671355

The Rabbit Polyclonal anti-ACVR2A antibody (ABIN5671355) specifically detects ACVR2A in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep and Zebrafish (Danio rerio) samples.

Quick Overview for ACVR2A antibody (C-Term) (ABIN5671355)

Target: ACVR2A (Activin A Receptor, Type IIA (ACVR2A))

Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR2A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACVR2A Antibody

Binding Specificity: C-Term

Sequence: AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against AVR2A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human AVR2A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACVR2A

Target: ACVR2A (Activin A Receptor, Type IIA (ACVR2A))

Alternative Name: AVR2A

Background: This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Alias Symbols: ACVR2A, ACVR2,

Protein Interaction Partner: BMP10, GDF2, ACVR1, INHBA, PEG10, ERBB2IP, UBC, IGSF1, MAGI2, TCTEX1D4, SYNJ2BP, GDF9, ACVRL1, INHBC, GDF5, TGFBR3, INHBB, ENG, BMP7, BMP6, ACVR1B, INHA,

Protein Size: 513

Gene ID: 92

NCBI Accession: NP_001607

UniProt: P27037