PHOX2B antibody (C-Term)

Catalog No. ABIN5671377

This Rabbit Polyclonal antibody specifically detects PHOX2B in WB. It exhibits reactivity toward Human.

Quick Overview for PHOX2B antibody (C-Term) (ABIN5671377)

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHOX2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PHOX2B Antibody

Binding Specificity: C-Term

Purpose: PHOX2B Antibody - C-terminal region

Sequence: RAAAAAAAAA KNGSSGKKSD SSRDDESKEA KSTDPDSTGG PGPNPNPTPS

Characteristics: This is a rabbit polyclonal antibody against PHX2B. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PHX2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP74127-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PHOX2B

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Alternative Name: PHOX2B

Background:

Background Information: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

Gene Name: paired like homeobox 2B

Alternative Symbols: CCHS, PMX2B, NBLST2, NBPhox

Protein Name: paired mesoderm homeobox protein 2B

Molecular Weight: 34kDa

Gene ID: 8929

NCBI Accession: NP_003915

UniProt: Q99453