EXOSC5 antibody (N-Term)

Catalog No. ABIN5672011

The Rabbit Polyclonal anti-EXOSC5 antibody (ABIN5672011) specifically detects EXOSC5 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for EXOSC5 antibody (N-Term) (ABIN5672011)

Target: EXOSC5 (Exosome Component 5 (EXOSC5))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EXOSC5 Antibody

Binding Specificity: N-Term

Sequence: CSLRHFACEQ NLLSRPDGSA SFLQGDTSVL AGVYGPAEVK VSKEIFNKAT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 91%

Characteristics: This is a rabbit polyclonal antibody against EXOS5. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human EXOS5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EXOSC5

Target: EXOSC5 (Exosome Component 5 (EXOSC5))

Alternative Name: EXOS5

Background: EXOS5 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation .

Alias Symbols: EXOSC5, CML28, RRP46,

Protein Interaction Partner: DOCK8, TRIM54, EXOSC1, FCHO1, IKZF3, EXOSC8, CALCOCO2, TNFAIP1, REL, KRT13, GOLGA2, BIRC2, UBC, rev, ZNF558, CDK5RAP1, EXOSC3, SRPK3, POLR2L, EXOSC10, PA2G4, LIPG, AICDA, DHRS2, EXOSC4, EXOSC2, PSIP1, EXOSC9, DIS3L, DIS3, CUL3, MEPCE, CDK9, SKIV2L2, EXOSC

Protein Size: 235

Gene ID: 56915

NCBI Accession: NP_064543

UniProt: Q9NQT4

Pathways: SARS-CoV-2 Protein Interactome