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POLD1 antibody
POLD1
Reactivity: Human, Rat, Mouse
WB
Host: Rat
Monoclonal
5G1
unconjugated
Product Details anti-POLD1 Antibody
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Target
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POLD1
(Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))
Reactivity
All reactivities for POLD1 antibodies
Human, Rat, Mouse
Host
All hosts for POLD1 antibodies
Rat
Clonality
All clonalities for POLD1 antibodies
Monoclonal
Conjugate
All conjugates for POLD1 antibodies
This POLD1 antibody is un-conjugated
Application
All applications for POLD1 antibodies
Western Blotting (WB)
Specificity
This antibody reacts with DNA polymerase delta p125 catalytic subunit (125 kDa) by Western blotting.
Purification
Protein-G Agarose Chromatography of hybridoma supernatant.
Immunogen
Recombinant full length His-Human p125.
Clone
5G1
Isotype
IgG2a
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS, pH 7.2 containing 50 % Glycerol without preservatives.
Preservative
Without preservative
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody (in aliquots) at -20 °C.
Target Details for POLD1
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Target
POLD1
(Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))
Alternative Name
POLD1 (POLD1 Products )
Synonyms
CDC2 antibody, CRCS10 antibody, POLD antibody, 5949 antibody, CAA61369 antibody, CG5949 antibody, DNA Pol Delta antibody, Dm Poldelta antibody, Dmel\\CG5949 antibody, Poldelta antibody, dnapol delta antibody, l(3)72Ac antibody, cdc2 antibody, pold antibody, 125kDa antibody, Pol delta antibody, fla antibody, im:7139126 antibody, zgc:152688 antibody, DNA polymerase delta 1, catalytic subunit antibody, DNA-polymerase-delta antibody, polymerase (DNA directed), delta 1, catalytic subunit antibody, DNA polymerase delta catalytic subunit antibody, DNA polymerase delta antibody, POLD1 antibody, DNApol-delta antibody, pold1 antibody, LOC100456571 antibody, Pold1 antibody
Background
In eukaryotic cells, 3 types of DNA polymerases (pol), pol alpha, pol delta and pol epsilon function in accurate and efficient DNA replication. Pol delta is a heteromultimeric enzyme composed of a 125 kDa major catalytic subunit and three smaller accessory subunits. Pol delta requires a number of accessory molecules to exert its full activity. Proliferating cell nuclear antigen (PCNA) forms a doughnut-shaped trimer with a 35 Ä hole and works as the sliding clamp and replication factor C acts as the clamp loader to improve Pol delta processivity. Pol delta is also involved in nucleotide excision repair of DNA.Synonyms: DNA polymerase delta catalytic subunit, DNA polymerase subunit delta p125
Gene ID
5424
NCBI Accession
NP_002682
UniProt
P28340
Pathways
Telomere Maintenance , DNA Damage Repair , DNA Replication , Chromatin Binding , Synthesis of DNA
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