TXNIP antibody

Catalog No. ABIN567793

This Mouse Monoclonal antibody specifically detects TXNIP in WB and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for TXNIP antibody (ABIN567793)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TXNIP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: JY1

Product Details anti-TXNIP Antibody

Specificity: This antibody reacts with VDUP-1 (50 kDa) by Western blotting.

Purification: Protein-A Agarose Chromatography of hybridoma supernatant.

Immunogen: Human recombinant VDUP-1/Txnip.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: TXNIP / VDUP1

Background: Vitamin D3 up-regulated protein 1 (VDUP-1), also called Thioredoxin (TRX)-interacting protein, is an endogenous inhibitor of TRX. Redox-dependent regulation of VDUP-1 by mitogenic factors through Reactive oxygen species (ROS) and the specific binding of VDUP-1 to the redox-sensitive cysteine-sulfide center of TRX modulate intracellular levels of ROS and the mitogenic activity of TRX.Synonyms: Thioredoxin-binding protein 2, Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1

Gene ID: 10628

NCBI Accession: NP_006463

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome