LAG3 antibody (N-Term) (Atto 590)

Catalog No. ABIN5688372

This Mouse Monoclonal antibody specifically detects LAG3 in ICC. It exhibits reactivity toward Human.

Quick Overview for LAG3 antibody (N-Term) (Atto 590) (ABIN5688372)

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAG3 antibody is conjugated to Atto 590

Application: Immunocytochemistry (ICC)

Clone: 17B4

Product Details anti-LAG3 Antibody (Atto 590)

Binding Specificity: N-Term

Specificity: Recognizes human LAG-3.

Purity: > 95% (SDS-PAGE)

Immunogen: Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.

Target Details for LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Alternative Name: LAG-3

Background: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Gene ID: 3902

UniProt: P18627

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints