Phospholipase C gamma 2 antibody (AA 1215-1219)

Catalog No. ABIN5689267

The Rabbit Polyclonal anti-Phospholipase C gamma 2 antibody is suitable to detect Phospholipase C gamma 2 in samples from Human, Rat and Mouse. It has been validated for IHC and IF.

Quick Overview for Phospholipase C gamma 2 antibody (AA 1215-1219) (ABIN5689267)

Target: Phospholipase C gamma 2 (PLCG2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase C gamma 2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Phospholipase C gamma 2 Antibody

Binding Specificity: AA 1215-1219

Specificity: This antibody detects endogenous level of total PLC-γ,2 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: PLC-gamma2 (Ab-1217) antibody was raised against a peptide sequence around aa.1215~1219 (F-L-Y-D-T) derived from Human PLCγ,2.

Application Details

Application Notes: Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for Phospholipase C gamma 2

Target: Phospholipase C gamma 2 (PLCG2)

Alternative Name: PLC gamma2

Background: The production of the second messenger molecules diacylglycerol. (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Molecular Weight: 150 kDa

Gene ID: 5336

NCBI Accession: NP_002652

UniProt: P16885

Pathways: RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling