JUP antibody (AA 726-730)

Catalog No. ABIN5689306

The Rabbit Polyclonal anti-JUP antibody has been validated for WB. It is suitable to detect JUP in samples from Human and Rat.

Quick Overview for JUP antibody (AA 726-730) (ABIN5689306)

Target: JUP (Junction Plakoglobin (JUP))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JUP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-JUP Antibody

Binding Specificity: AA 726-730

Specificity: This antibody detects endogenous levels of total gamma-Catenin protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: gamma-Catenin antibody was raised in was raised against a peptide sequence around aa.726~730 (I-D-T-Y-S) derived from Human gamma-Catenin.

Application Details

Application Notes: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for JUP

Target: JUP (Junction Plakoglobin (JUP))

Alternative Name: gamma Catenin 

Background: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton

Molecular Weight: 83 kDa

Gene ID: 3728

NCBI Accession: NP_002221

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location