DIS3L2 antibody (AA 720-770)
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- Target See all DIS3L2 Antibodies
- DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))
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Binding Specificity
- AA 720-770
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DIS3L2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist, this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.
- Purification
- DIS3L2 antibody is affinity chromatography purified via peptide column.
- Immunogen
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DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2.
The immunogen is located within amino acids 720 - 770 of DIS3L2. - Isotype
- IgG
- Top Product
- Discover our top product DIS3L2 Primary Antibody
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- Application Notes
- DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- DIS3L2 antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- DIS3L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- Target
- DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))
- Alternative Name
- DIS3L2 (DIS3L2 Products)
- Synonyms
- RGD1560168 antibody, DIS3L2 antibody, DKFZp469O0522 antibody, FAM6A antibody, PRLMNS antibody, hDIS3L2 antibody, 4930429A22Rik antibody, 8030493P09Rik antibody, DIS3-like 3'-5' exoribonuclease 2 antibody, DIS3 like 3'-5' exoribonuclease 2 antibody, DIS3-like exonuclease 2 antibody, Dis3l2 antibody, DIS3L2 antibody, LOC100344728 antibody
- Background
- The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).
- Molecular Weight
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Predicted: 97 kDa
Observed: 94 kDa - Gene ID
- 129563
- NCBI Accession
- NP_689596
- UniProt
- Q8IYB7
- Pathways
- Stem Cell Maintenance
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