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KREMEN2 antibody (AA 390-440)
KREMEN2
Reactivity: Human, Mouse
WB, ELISA, ICC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-KREMEN2 Antibody
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Target
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KREMEN2
(Kringle Containing Transmembrane Protein 2 (KREMEN2))
Binding Specificity
All epitopes for KREMEN2 antibodies
AA 390-440
Reactivity
All reactivities for KREMEN2 antibodies
Human, Mouse
Host
All hosts for KREMEN2 antibodies
Rabbit
Clonality
All clonalities for KREMEN2 antibodies
Polyclonal
Conjugate
All conjugates for KREMEN2 antibodies
This KREMEN2 antibody is un-conjugated
Application
All applications for KREMEN2 antibodies
Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
Specificity
Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.
Purification
KREMEN2 Antibody is affinity chromatography purified via peptide column.
Immunogen
KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 . The immunogen is located within amino acids 390 - 440 of KREMEN2.
Isotype
IgG
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Discover our top product KREMEN2 Primary Antibody
Alternatives
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Application Details
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Application Notes
KREMEN2 Antibody can be used for detection of KREMEN2 by Western blot starting at 1 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
KREMEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
KREMEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for KREMEN2
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Target
KREMEN2
(Kringle Containing Transmembrane Protein 2 (KREMEN2))
Alternative Name
KREMEN2 (KREMEN2 Products )
Synonyms
krm2 antibody, KREMEN2 antibody, MGC147633 antibody, KRM2 antibody, 2900054E04Rik antibody, Krm2 antibody, kringle containing transmembrane protein 2 S homeolog antibody, kringle containing transmembrane protein 2 antibody, kremen2.S antibody, KREMEN2 antibody, kremen2 antibody, Kremen2 antibody
Background
KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
Molecular Weight
Predicted: 51 kDa Observed: 54 kDa
Gene ID
79412
NCBI Accession
NP_757384
UniProt
Q8NCW0
Pathways
WNT Signaling
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