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Bestrophin 1 antibody

BEST1 Reactivity: Human WB, IHC, FACS, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5692801
  • Target See all Bestrophin 1 (BEST1) Antibodies
    Bestrophin 1 (BEST1)
    Reactivity
    • 26
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 21
    • 5
    Rabbit
    Clonality
    • 23
    • 3
    Polyclonal
    Conjugate
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Bestrophin 1 antibody is un-conjugated
    Application
    • 17
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Brand
    Picoband™
    Sequence
    RFIYRLALTE EQQLMFEKLT LYCD
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Bestrophin detection. Tested with WB, IHC-F, ICC, FCM in Human.
    Immunogen
    A synthetic peptide corresponding to a sequence of human Bestrophin (RFIYRLALTEEQQLMFEKLTLYCD).
    Top Product
    Discover our top product BEST1 Primary Antibody
  • Application Notes

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(F) and ICC.

    Application Details: Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry(Frozen Section), 0.5-1 μg/mL
    Immunocytochemistry, 0.5-1 μg/mL
    Flow Cytometry, 1-3 μg/1x106 cells

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Target
    Bestrophin 1 (BEST1)
    Alternative Name
    BEST1 (BEST1 Products)
    Synonyms
    CG6264 antibody, Dbest antibody, Dmel\\CG6264 antibody, anon-WO0118547.380 antibody, best antibody, dBest1 antibody, dbest1 antibody, dmBest1 antibody, BEST1 antibody, VMD2 antibody, best-1 antibody, ARB antibody, BEST antibody, BMD antibody, RP50 antibody, TU15B antibody, Bmd antibody, Vmd2 antibody, mBest1 antibody, Bestrophin 1 antibody, bestrophin 1 antibody, Best1 antibody, BEST1 antibody, best1 antibody, Bm1_25500 antibody
    Background

    Synonyms: Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2

    Tissue Specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

    Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

    UniProt
    O76090
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