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CHM antibody (Choroideremia (Rab Escort Protein 1)) (AA 193-380) Primary Antibody

CHM Reactivity: Human, Mouse, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5693178
$240.00
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100 μg
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  • Target
    CHM
    Binding Specificity
    AA 193-380
    • 16
    • 9
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Reactivity
    Human, Mouse, Rat
    • 39
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    Host
    Rabbit
    • 34
    • 5
    Clonality
    Polyclonal
    • 39
    Conjugate
    This CHM antibody is un-conjugated
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    ELISA, Western Blotting (WB)
    • 30
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for CHM detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
    Immunogen
    E. coli-derived human CHM recombinant protein (Position: A193-Q380).
  • Application Notes

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

    Application Details: Western blot, 0.1-0.5&mu,g/mL
    Direct ELISA, 0.1-0.5&mu,g/mL

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Target
    CHM
    Alternative Name
    CHM (CHM Antibody Abstract)
    Synonyms
    CHM, REP1, DXS540, GGTA, HSD-32, REP-1, TCD, DKFZp459K2154, tcd, ggta, rep-1, dxs540, hsd-32, MGC68578, Rep-1, chm, chm-a, chm-b, chml, CHM, Rab escort protein 1, choroideremia (Rab escort protein 1), choroideremia (Rab escort protein 1) L homeolog, choroidermia (RAB escort protein 1), choroideremia (Rab escort protein 1) S homeolog, CHM, chm, chm.L, Chm, chm.S
    Background

    Synonyms: Rab proteins geranylgeranyltransferase component A 1, Choroideremia protein, Rab escort protein 1, REP-1, TCD protein, CHM, REP1, TCD

    Background: Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene. This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia, also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.

    UniProt
    P24386
    Pathways
    Sensory Perception of Sound
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