BHLHE41 antibody

Catalog No. ABIN5702192

The Rabbit Polyclonal anti-BHLHE41 antibody is suitable to detect BHLHE41 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IP.

Quick Overview for BHLHE41 antibody (ABIN5702192)

Target: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BHLHE41 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-BHLHE41 Antibody

Purpose: BHLHE41 antibody

Immunogen:

Immunogen sequence: 419-482

Immunogen: basic helix-loop-helix family, member e41

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for BHLHE41

Target: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Alternative Name: BHLHE41

Background:

Synonyms: Class E basic helix-loop-helix protein 41 (bHLHe41)|Class B basic helix-loop-helix protein 3 (bHLHb3)|Differentially expressed in chondrocytes protein 2 (hDEC2)|Enhancer-of-split and hairy-related protein 1 (SHARP-1)|BHLHE41|BHLHB3|DEC2|SHARP1

Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Molecular Weight: 51 kDa,75 kDa

Gene ID: 79365

UniProt: Q9C0J9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development