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BHLHE41 antibody (AA 185-285)

BHLHE41 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7147841
  • Target See all BHLHE41 Antibodies
    BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))
    Binding Specificity
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 185-285
    Reactivity
    • 39
    • 21
    • 14
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 30
    • 8
    • 1
    Rabbit
    Clonality
    • 32
    • 7
    Polyclonal
    Conjugate
    • 23
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BHLHE41 antibody is un-conjugated
    Application
    • 28
    • 18
    • 7
    • 4
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA)
    Isotype
    IgG
    Top Product
    Discover our top product BHLHE41 Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:500-1:5000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))
    Alternative Name
    BHLHE41 (BHLHE41 Products)
    Synonyms
    BHLHB3 antibody, dec2 antibody, bhlhb3 antibody, sharp1 antibody, sharp-1 antibody, MGC108143 antibody, DEC2 antibody, SHARP1 antibody, hDEC2 antibody, 6430520M22Rik antibody, Bhlhb2l antibody, Bhlhb3 antibody, Sharp1 antibody, Dec2 antibody, SHARP-1 antibody, basic helix-loop-helix family member e41 antibody, basic helix-loop-helix family, member e41 antibody, BHLHE41 antibody, bhlhe41 antibody, Bhlhe41 antibody
    Background

    Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5\\\'-CACGTG-3\\\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

    Aliases: Basic helix-loop-helix domain containing class B3 antibody, BHE41_HUMAN antibody, bHLH protein DEC2 antibody, bHLHB3 antibody, bHLHe41 antibody, Class B basic helix loop helix protein 3 antibody, Class B basic helix-loop-helix protein 3 antibody, Class E basic helix-loop-helix protein 41 antibody, DEC2 antibody, Differentially expressed in chondrocytes protein 2 antibody, Enhancer of split and hairy related protein 1 antibody, Enhancer-of-split and hairy-related protein 1 antibody, hDEC2 antibody, Moderately similar to basic-helix loop helix protein M.musculus antibody, SHARP-1 antibody

    UniProt
    Q9C0J9
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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