KEAP1 antibody (AA 378-486)

Catalog No. ABIN5702287

This Rabbit Polyclonal antibody specifically detects KEAP1 in WB, ELISA, IHC and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for KEAP1 antibody (AA 378-486) (ABIN5702287)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KEAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-KEAP1 Antibody

Binding Specificity: AA 378-486

Purpose: KEAP1 antibody

Immunogen:

Immunogen sequence: 378-486aa

Immunogen: kelch-like ECH-associated protein 1

Isotype: IgG

Application Details

Application Notes: WB : 1:1000-1:10000 IP : 1:200-1:2000 IHC : 1:50-1:200

Comment:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04516(KEAP1 antibody) at dilution of 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Alternative Name: KEAP1

Background:

Synonyms: Kelch-like ECH-associated protein 1|Cytosolic inhibitor of Nrf2 (INrf2)|Kelch-like protein 19|KEAP1|INRF2|KIAA0132|KLHL19

Background: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Molecular Weight: 55-70 kDa

Gene ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location