IFIH1 antibody (AA 1-210)

Catalog No. ABIN5703110

The Rabbit Polyclonal anti-IFIH1 antibody is suitable to detect IFIH1 in samples from Human. It has been validated for WB, ELISA and IP.

Quick Overview for IFIH1 antibody (AA 1-210) (ABIN5703110)

Target: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-IFIH1 Antibody

Binding Specificity: AA 1-210

Purpose: IFIH1 antibody

Immunogen:

Immunogen sequence: 1-210aa

Immunogen: interferon induced with helicase C domain 1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for IFIH1

Target: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Alternative Name: IFIH1

Background:

Synonyms: Interferon-induced helicase C domain-containing protein 1|Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen)|Helicase with 2 CARD domains (Helicard)|Interferon-induced with helicase C domain protein 1|Melanoma differentiation-associated protein 5 (MDA-5)|Murabutide down-regulated protein|RIG-I-like receptor 2 (RLR-2)|RNA helicase-DEAD box protein 116|IFIH1|MDA5|RH116

Background: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA(>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein(MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons(IFNs), IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus(EMCV) and mengo encephalomyocarditis virus(ENMG). Can also detect other viruses such as dengue virus(DENV), west Nile virus(WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L(RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Molecular Weight: 117-125 kDa

Gene ID: 64135

UniProt: Q9BYX4

Pathways: Activation of Innate immune Response