COCH antibody

Catalog No. ABIN5703508

This Rabbit Polyclonal antibody specifically detects COCH in ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for COCH antibody (ABIN5703508)

Target: COCH (Cochlin (COCH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COCH antibody is un-conjugated

Application: ELISA

Product Details anti-COCH Antibody

Immunogen: coagulation factor C homolog, cochlin (Limulus polyphemus)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for COCH

Target: COCH (Cochlin (COCH))

Alternative Name: COCH

Background: Synonyms:COCH5B2 Background:The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

Gene ID: 1690

UniProt: O43405

Pathways: Sensory Perception of Sound