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NGFR antibody

This anti-NGFR antibody is a Rabbit Monoclonal antibody detecting NGFR in IHC (p). Suitable for Human, Rat and Non-Human Primate.
Catalog No. ABIN5707549

Quick Overview for NGFR antibody (ABIN5707549)

Target

See all NGFR Antibodies
NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivity

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Human, Rat, Non-Human Primate

Host

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Rabbit

Clonality

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Monoclonal

Conjugate

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This NGFR antibody is un-conjugated

Application

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone

NGFR-1997R
  • Cross-Reactivity (Details)

    Not suitable for mouse

    Purification

    Purified

    Purity

    Protein A affinity chromatography

    Immunogen

    Recombinant human protein was used as the immunogen for the recombinant p75NTR antibody.

    Isotype

    IgG kappa
  • Application Notes

    Optimal dilution of the recombinant p75NTR antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

    Restrictions

    For Research Use only
  • Buffer

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store the recombinant p75NTR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • Target

    NGFR (Nerve Growth Factor Receptor (NGFR))

    Alternative Name

    NGF Receptor / p75NTR / CD271

    Background

    This antibody is specific for a glycoprotein of 75  kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or p75 Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR/p75NTR is a reliable marker for desmoplastic and neurotropic melanomas. It is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR/p75NTR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

    Pathways

    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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