ABCE1 antibody (AA 419-599)

Catalog No. ABIN5708515

The Rabbit Polyclonal anti-ABCE1 antibody (ABIN5708515) specifically detects ABCE1 in WB, FACS, IF and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ABCE1 antibody (AA 419-599) (ABIN5708515)

Target: ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCE1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-ABCE1 Antibody

Binding Specificity: AA 419-599

Purpose: ABCE1 Antibody

Purification: Antigen affinity

Immunogen: Amino acids K419-D599 from the human protein were used as the immunogen for the ABCE1 antibody.

Isotype: IgG

Application Details

Application Notes: Differences in protocols and secondary/substrate sensitivity may require the ABCE1 antibody to be titrated for optimal performance.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ABCE1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ABCE1

Target: ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))

Alternative Name: ABCE1 / ATP binding cassette E1

Background: ATP binding cassette E1 (ABCE1, also called RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.

UniProt: P61221