ABCE1 antibody (AA 141-599)

Catalog No. ABIN7870676

This Rabbit Polyclonal antibody specifically detects ABCE1 in WB and IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for ABCE1 antibody (AA 141-599) (ABIN7870676)

Target: ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ABCE1 Antibody

Binding Specificity: AA 141-599

Purpose: Zebrafish ATP binding cassette E1 Antibody / Abce1

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish ABCE1 recombinant protein (amino acids Q141-D599) was used as the immunogen for the Zebrafish ATP binding cassette E1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish ATP binding cassette E1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish ATP binding cassette E1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ABCE1

Target: ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))

Alternative Name: ATP binding cassette E1

Background: ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.

UniProt: Q6TNW3