GRIA2 antibody (Ser880)

Catalog No. ABIN5956617

The Rabbit Polyclonal anti-GRIA2 antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect GRIA2 in samples from Human, Rat and Mouse.

Quick Overview for GRIA2 antibody (Ser880) (ABIN5956617)

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GRIA2 Antibody

Binding Specificity: Ser880

Specificity: AMPA 2,AMPA selective glutamate receptor 2,AMPA-selective glutamate receptor 2,AMPA2,GluA2,GLUR 2,GLUR B,GluR K2,GluR-2,GluR-B,GluR-K2,GLUR2,GLURB,Glutamate receptor 2,Glutamate receptor ionotropic AMPA 2,Glutamate receptor ionotropic,Gria2,GRIA2,HBGR2

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human GluR-2 around the non-phosphorylation site of Ser880.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Alternative Name: GluR-2

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Molecular Weight: 99kDa

Gene ID: 2891

UniProt: P42262

Pathways: PI3K-Akt Signaling