TYK2 antibody (Tyr1054)

Catalog No. ABIN5957298

The Rabbit Polyclonal anti-TYK2 antibody is suitable to detect TYK2 in samples from Human, Mouse and Monkey. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for TYK2 antibody (Tyr1054) (ABIN5957298)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TYK2 Antibody

Binding Specificity: Tyr1054

Specificity: JTK 1,JTK1,Non receptor tyrosine protein kinase 2,Non receptor tyrosine protein kinase TYK2,Non-receptor tyrosine-protein kinase TYK2,OTTHUMP00000232745,OTTHUMP00000232746,OTTHUMP00000232748,Protein Tyrosine Kinase 2,TYK 2,Tyk2,TYK2,Tyrosine kinase 2

Purification: Affinity purification

Immunogen: Synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Tyr1054.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: Tyk 2

Background: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Primary Cutaneous Anaplastic Large Cell Lymphoma. Among its related pathways are Type I Interferon Signaling Pathways and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.

Molecular Weight: 134kDa

Gene ID: 7297

UniProt: P29597

Pathways: JAK-STAT Signaling, Hepatitis C