CTLA4 antibody (Biotin)

Catalog No. ABIN610401

The Biotin-conjugated Mouse Monoclonal anti-CTLA4 antibody (Clone ANC152-2-8H5) (ABIN610401) specifically detects CTLA4 in FACS, ELISA and Func. The antibody is reactive with Human samples.

Quick Overview for CTLA4 antibody (Biotin) (ABIN610401)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTLA4 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Clone: ANC152-2-8H5

Product Details anti-CTLA4 Antibody (Biotin)

Specificity: CTLA-4 expressed on activated T cells.

Purification: Protein A purified

Immunogen: Stimulated human PBL’,s and human CD152 Ig fusion protein.

Type of Immunogen: Fusion protein

Isotype: IgG1 kappa

Application Details

Application Notes: Approved: ELISA, Flo, Func

Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CTLA4 / CD152

Background: Name/Gene ID: CTLA4

Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform

Gene ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints