CTLA4 antibody

Catalog No. ABIN610403

The Mouse Monoclonal anti-CTLA4 antibody is suitable to detect CTLA4 in samples from Human. It has been validated for FACS, ELISA and Func.

Quick Overview for CTLA4 antibody (ABIN610403)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Fragment: F(ab')2 fragment

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTLA4 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Clone: ANC152-2-8H5

Product Details anti-CTLA4 Antibody

Specificity: CTLA-4 expressed on activated T cells.

Purification: Gel filtration

Sterility: 0.1 μm filtered

Immunogen: Stimulated human PBL’,s and human CD152 Ig fusion protein.

Type of Immunogen: Fusion protein

Isotype: IgG1 kappa

Application Details

Application Notes: Approved: ELISA, Flo, Func

Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride. Product was 0.1 μm filtered, vialed under aseptic conditions. No preservative added

Preservative: Without preservative

Handling Advice: Do not freeze. Open under aseptic conditions.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Open under aseptic conditions.

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CTLA4 / CD152

Background: Name/Gene ID: CTLA4

Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform

Gene ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints