RPS6KB1 antibody (pSer424, pThr421)

Catalog No. ABIN6136296

This Rabbit Monoclonal antibody specifically detects RPS6KB1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for RPS6KB1 antibody (pSer424, pThr421) (ABIN6136296)

Target: RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RPS6KB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-RPS6KB1 Antibody

Binding Specificity: pSer424, pThr421

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Phospho-S6K1 (T421 + S424).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RPS6KB1

Target: RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))

Alternative Name: RPS6KB1

Background: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013],PS6K,S6K,S6K-beta-1,S6K1,STK14A,p70 S6KA,p70(S6K)-alpha,p70-S6K,p70-alpha,P70 S6K,RPS6KB1,p70S6KA,AMPK Signaling Pathway,Angiogenesis,Apoptosis,Apoptosis_Inhibition of Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,B Cell Receptor Signaling Pathway,Cardiovascular,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Cell cycle inhibitors,DNA Damage & Repair,Endocrine & Metabolism,Endocrine and metabolic diseases,Endocrine and metabolic diseases_Obesity,Epigenetics & Nuclear Signaling,ErbB-HER Signaling Pathway,Immunology & Inflammation,Insulin Receptor Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,mTOR Signaling Pathway,PI3K-Akt Signaling Pathway,PI3K-Akt Signaling Pathway_Akt downstream targets,Protein Kinase C Signaling Pathway Pathway,Protein phosphorylation,Signal Transduction,TGF-b-Smad Signaling Pathway,Translation Control,Translational Control_Regulation of eIF4 and p70 S6 Kinase,RPS6KB1

Molecular Weight: 70 kDa

Gene ID: 6198

UniProt: P23443

Pathways: PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, Skeletal Muscle Fiber Development, Feeding Behaviour, G-protein mediated Events, Smooth Muscle Cell Migration, Interaction of EGFR with phospholipase C-gamma, Warburg Effect