Cathepsin D antibody (AA 65-412)

Catalog No. ABIN6139223

This anti-Cathepsin D antibody is a Rabbit Polyclonal antibody detecting Cathepsin D in WB and IHC. Suitable for Human.

Quick Overview for Cathepsin D antibody (AA 65-412) (ABIN6139223)

Target: Cathepsin D (CTSD)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin D antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Cathepsin D Antibody

Binding Specificity: AA 65-412

Sequence: GPIPEVLKNY MDAQYYGEIG IGTPPQCFTV VFDTGSSNLW VPSIHCKLLD IACWIHHKYN SDKSSTYVKN GTSFDIHYGS GSLSGYLSQD TVSVPCQSAS SASALGGVKV ERQVFGEATK QPGITFIAAK FDGILGMAYP RISVNNVLPV FDNLMQQKLV DQNIFSFYLS RDPDAQPGGE LMLGGTDSKY YKGSLSYLNV TRKAYWQVHL DQVEVASGLT LCKEGCEAIV DTGTSLMVGP VDEVRELQKA IGAVPLIQGE YMIPCEKVST LPAITLKLGG KGYKLSPEDY TLKVSQAGKT LCLSGFMGMD IPPPSGPLWI LGDVFIGRYY TVFDRDNNRV GFAEAARL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 65-412 of human Cathepsin D (NP_001900.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: CTSD

Background: This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.,CLN10,CPSD,HEL-S-130P,Cathepsin D,CTSD,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Extracellular Matrix,Ubiquitin,Neuroscience,CTSD

Molecular Weight: 44 kDa

Gene ID: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism