DNAJB14 antibody (AA 1-120)

Catalog No. ABIN6139706

The Rabbit Polyclonal anti-DNAJB14 antibody (ABIN6139706) specifically detects DNAJB14 in WB. The antibody is reactive with Human samples.

Quick Overview for DNAJB14 antibody (AA 1-120) (ABIN6139706)

Target: DNAJB14 (DnaJ (Hsp40) Homolog, Subfamily B, Member 14 (DNAJB14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJB14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DNAJB14 Antibody

Binding Specificity: AA 1-120

Sequence: MEGNRDEAEK CVEIAREALN AGNREKAQRF LQKAEKLYPL PSARALLEII MKNGSTAGNS PHCRKPSGSG DQSKPNCTKD STSGSGEGGK GYTKDQVDGV LSINKCKNYY EVLGVTKDAG

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DNAJB14 (NP_001026893.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DNAJB14

Target: DNAJB14 (DnaJ (Hsp40) Homolog, Subfamily B, Member 14 (DNAJB14))

Alternative Name: DNAJB14

Background: Acts as a co-chaperone with HSPA8/Hsc70, required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus, the role of these structures, named DJANGOs, is still unclear.,DNAJB14,EGNR9427,PRO34683,Epigenetics & Nuclear Signaling,Signal Transduction,DNAJB14

Molecular Weight: 33 kDa/42 kDa

Gene ID: 79982

UniProt: Q8TBM8