ELANE antibody (AA 30-267)

Catalog No. ABIN6140110

This Rabbit Polyclonal antibody specifically detects ELANE in WB and IF. It exhibits reactivity toward Human.

Quick Overview for ELANE antibody (AA 30-267) (ABIN6140110)

Target: ELANE (Elastase, Neutrophil Expressed (ELANE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELANE antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ELANE Antibody

Binding Specificity: AA 30-267

Sequence: IVGGRRARPH AWPFMVSLQL RGGHFCGATL IAPNFVMSAA HCVANVNVRA VRVVLGAHNL SRREPTRQVF AVQRIFENGY DPVNLLNDIV ILQLNGSATI NANVQVAQLP AQGRRLGNGV QCLAMGWGLL GRNRGIASVL QELNVTVVTS LCRRSNVCTL VRGRQAGVCF GDSGSPLVCN GLIHGIASFV RGGCASGLYP DAFAPVAQFV NWIDSIIQRS EDNPCPHPRD PDPASRTH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-267 of human Neutrophil Elastase (ELANE) (NP_001963.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ELANE

Target: ELANE (Elastase, Neutrophil Expressed (ELANE))

Alternative Name: ELANE

Background: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.,ELANE,ELA2,GE,HLE,HNE,NE,PMN-E,SCN1,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,ELANE

Molecular Weight: 28 kDa

Gene ID: 1991

UniProt: P08246