IRS2 antibody (AA 510-650)

Catalog No. ABIN6142544

Product Details anti-IRS2 Antibody

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Binding Specificity: AA 510-650

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: LRAFCSHRSN TPESIAETPP ARDGGGGGEF YGYMTMDRPL SHCGRSYRRV SGDAAQDLDR GLRKRTYSLT TPARQRPVPQ PSSASLDEYT LMRATFSGSA GRLCPSCPAS SPKVAYHPYP EDYGDIEIGS HRSSSSNLGA D

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 510-650 of human IRS2 (NP_003740.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IRS2

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Alternative Name: IRS2 (IRS2 Products)

Synonyms: IRS2 antibody, si:dkeyp-24d6.1 antibody, IRS-2 antibody, 4PS antibody, Irs-2 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 2a antibody, insulin receptor substrate 2b antibody, IRS2 antibody, irs2a antibody, irs2b antibody, Irs2 antibody

Background: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.,IRS2,IRS-2,Cancer,Signal Transduction,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Endocrine and metabolic diseases,Diabetes,Immunology & Inflammation,Cardiovascular,Heart,Cardiovascular diseases,Heart disease,IRS2

Molecular Weight: 137 kDa

Gene ID: 8660

UniProt: Q9Y4H2

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process