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LAMC2 antibody (AA 862-1111)

LAMC2 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6143076
  • Target See all LAMC2 Antibodies
    LAMC2 (Laminin, gamma 2 (LAMC2))
    Binding Specificity
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 862-1111
    Reactivity
    • 28
    • 24
    • 8
    • 1
    • 1
    • 1
    Human
    Host
    • 45
    • 3
    Rabbit
    Clonality
    • 46
    • 2
    Polyclonal
    Conjugate
    • 23
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LAMC2 antibody is un-conjugated
    Application
    • 37
    • 22
    • 12
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    SDQSFQVEEA KRIKQKADSL SSLVTRHMDE FKRTQKNLGN WKEEAQQLLQ NGKSGREKSD QLLSRANLAK SRAQEALSMG NATFYEVESI LKNLREFDLQ VDNRKAEAEE AMKRLSYISQ KVSDASDKTQ QAERALGSAA ADAQRAKNGA GEALEISSEI EQEIGSLNLE ANVTADGALA MEKGLASLKS EMREVEGELE RKELEFDTNM DAVQMVITEA QKVDTRAKNA GVTIQDTLNT LDGLLHLMGM
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 862-1111 of human LAMC2 (NP_061486.2).
    Isotype
    IgG
    Top Product
    Discover our top product LAMC2 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    LAMC2 (Laminin, gamma 2 (LAMC2))
    Alternative Name
    LAMC2 (LAMC2 Products)
    Synonyms
    LAMC2 antibody, B2T antibody, BM600 antibody, CSF antibody, EBR2 antibody, EBR2A antibody, LAMB2T antibody, LAMNB2 antibody, AA589349 antibody, laminin subunit gamma 2 antibody, laminin, gamma 2 antibody, LAMC2 antibody, Lamc2 antibody
    Background
    This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain, however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.,LAMC2,B2T,BM600,CSF,EBR2,EBR2A,LAMB2T,LAMNB2,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Neuroscience,LAMC2
    Molecular Weight
    121 kDa/130 kDa
    Gene ID
    3918
    UniProt
    Q13753
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