MORF4L1 antibody (AA 1-100)
Quick Overview for MORF4L1 antibody (AA 1-100) (ABIN6143948)
Target
See all MORF4L1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 1-100
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Sequence
- MAPKQDPKPK FQEGERVLCF HGPLLYEAKC VKVAIKDKQV KYFIHYSGWN KNWDEWVPES RVLKYVDTNL QKQRELQKAN QEQYAEGKMR GAAPGKKTSG
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Cross-Reactivity
- Human, Mouse, Rat
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Characteristics
- Polyclonal Antibodies
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Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MORF4L1 (NP_006782.1).
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Isotype
- IgG
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Application Notes
- WB,1:500 - 1:2000
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Comment
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HIGH QUALITY
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))
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Alternative Name
- MORF4L1
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Background
- Component of the NuA4 histone acetyltransferase (HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR and resistance to mitomycin C (MMC. Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.,MORF4L1,Eaf3,FWP006,HsT17725,MEAF3,MORFRG15,MRG15,S863-6,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,MORF4L1
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Molecular Weight
- 26 kDa/37 kDa/41 kDa
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Gene ID
- 10933
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UniProt
- Q9UBU8
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Pathways
- Chromatin Binding
Target
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