Merlin antibody (AA 477-576)

Catalog No. ABIN6144548

The Rabbit Polyclonal anti-Merlin antibody has been validated for WB, IF and IP. It is suitable to detect Merlin in samples from Human.

Quick Overview for Merlin antibody (AA 477-576) (ABIN6144548)

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Merlin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-Merlin Antibody

Binding Specificity: AA 477-576

Sequence: TKPTYPPMNP IPAPLPPDIP SFNLIGDSLS FDFKDTDMKR LSMEIEKEKV EYMEKSKHLQ EQLNELKTEI EALKLKERET ALDILHNENS DRGGSSKHNT

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 477-576 of human NF2 (NP_000259.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Alternative Name: NF2

Background: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.,NF2,ACN,BANF,SCH,merlin,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Hippo Signaling Pathway,Neuroscience,NF2

Molecular Weight: 19-30 kDa/59-72 kDa

Gene ID: 4771

UniProt: P35240

Pathways: Cell-Cell Junction Organization