Nodal antibody (AA 198-347)

Catalog No. ABIN6144699

This Rabbit Polyclonal antibody specifically detects Nodal in WB. It exhibits reactivity toward Human.

Quick Overview for Nodal antibody (AA 198-347) (ABIN6144699)

Target: Nodal (NODAL) (Nodal Homolog (NODAL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nodal antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Nodal Antibody

Binding Specificity: AA 198-347

Sequence: SNLSQEQRQL GGSTLLWEAE SSWRAQEGQL SWEWGKRHRR HHLPDRSQLC RKVKFQVDFN LIGWGSWIIY PKQYNAYRCE GECPNPVGEE FHPTNHAYIQ SLLKRYQPHR VPSTCCAPVK TKPLSMLYVD NGRVLLDHHK DMIVEECGCL

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 198-347 of human NODAL (NP_060525.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Nodal

Target: Nodal (NODAL) (Nodal Homolog (NODAL))

Alternative Name: NODAL

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis.,NODAL,HTX5,Cell Biology & Developmental Biology,Growth factor,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,Immunology & Inflammation,Cytokines,Stem Cells,Embryonic Stem Cells,Ligand,NODAL

Molecular Weight: 39 kDa

Gene ID: 4838

UniProt: Q96S42

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of Endopeptidase Activity