POLG antibody (AA 980-1239)

Catalog No. ABIN6145892

This Rabbit Polyclonal antibody specifically detects POLG in WB. It exhibits reactivity toward Human.

Quick Overview for POLG antibody (AA 980-1239) (ABIN6145892)

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLG antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-POLG Antibody

Binding Specificity: AA 980-1239

Sequence: EKAQQMYAAT KGLRWYRLSD EGEWLVRELN LPVDRTEGGW ISLQDLRKVQ RETARKSQWK KWEVVAERAW KGGTESEMFN KLESIATSDI PRTPVLGCCI SRALEPSAVQ EEFMTSRVNW VVQSSAVDYL HLMLVAMKWL FEEFAIDGRF CISIHDEVRY LVREEDRYRA ALALQITNLL TRCMFAYKLG LNDLPQSVAF FSAVDIDRCL RKEVTMDCKT PSNPTGMERR YGIPQGEALD IYQIIELTKG SLEKRSQPGP

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 980-1239 of human DNA Polymerase gamma (NP_002684.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for POLG

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Alternative Name: POLG

Target Type: Viral Protein

Background: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.,POLG,MDP1,MIRAS,MTDPS4A,MTDPS4B,PEO,POLG1,POLGA,SANDO,SCAE,Epigenetics & Nuclear Signaling,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial Biogenesis,Nucleotide metabolism,Molecular processes,POLG

Molecular Weight: 139 kDa

Gene ID: 5428

UniProt: P54098