SETD2 antibody (AA 803-1103)

Catalog No. ABIN6147638

The Rabbit Polyclonal anti-SETD2 antibody has been validated for WB. It is suitable to detect SETD2 in samples from Human.

Quick Overview for SETD2 antibody (AA 803-1103) (ABIN6147638)

Target: SETD2 (SET Domain Containing 2 (SETD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SETD2 Antibody

Binding Specificity: AA 803-1103

Sequence: SLCNSEAENI EPSVMKISSN SFMNVHLESK PVICDSRNLT DHSKFACEEY KQSIGSTSSA SVNHFDDLYQ PIGSSGIASS LQSLPPGIKV DSLTLLKCGE NTSPVLDAVL KSKKSSEFLK HAGKETIVEV GSDLPDSGKG FASRENRRNN GLSGKCLQEA QEEGNSILPE RRGRPEISLD ERGEGGHVHT SDDSEVVFSS CDLNLTMEDS DGVTYALKCD SSGHAPEIVS TVHEDYSGSS ESSNDESDSE DTDSDDSSIP RNRLQSVVVV PKNSTLPMEE TSPCSSRSSQ SYRHYSDHWE D

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SETD2

Target: SETD2 (SET Domain Containing 2 (SETD2))

Alternative Name: SETD2

Background: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.,SETD2,HBP231,HIF-1,HIP-1,HSPC069,HYPB,KMT3A,LLS,SET2,p231HBP,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,SETD2

Molecular Weight: 175 kDa/192 kDa/287 kDa

Gene ID: 29072

UniProt: Q9BYW2

Pathways: Tube Formation