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SMN2 antibody (AA 1-197)

SMN2 Reactivity: Human WB, IF, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6148134
  • Target See all SMN2 Antibodies
    SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
    Binding Specificity
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-197
    Reactivity
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 6
    • 5
    Rabbit
    Clonality
    • 8
    • 3
    Polyclonal
    Conjugate
    • 11
    This SMN2 antibody is un-conjugated
    Application
    • 9
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
    Sequence
    MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS DNIKPKSAPW NSFLPPP
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human SMN2 (NP_059107.1).
    Isotype
    IgG
    Top Product
    Discover our top product SMN2 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:20 - 1:50
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
    Alternative Name
    SMN2 (SMN2 Products)
    Synonyms
    BCD541 antibody, C-BCD541 antibody, GEMIN1 antibody, SMNC antibody, TDRD16B antibody, bcd541 antibody, c-bcd541 antibody, gemin-1 antibody, smn2 antibody, smnc antibody, survival of motor neuron 2, centromeric antibody, survival of motor neuron 2, centromeric L homeolog antibody, SMN2 antibody, smn2.L antibody
    Background
    This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.,SMN2,BCD541,C-BCD541,GEMIN1,SMNC,TDRD16B,SMN2
    Molecular Weight
    27 kDa/28 kDa/30 kDa/31 kDa
    Gene ID
    6607
    UniProt
    Q16637
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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