TEK antibody (AA 500-750)

Catalog No. ABIN6148993

The Rabbit Polyclonal anti-TEK antibody has been validated for WB and IHC. It is suitable to detect TEK in samples from Human. There are 2+ publications available.

Quick Overview for TEK antibody (AA 500-750) (ABIN6148993)

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TEK Antibody

Binding Specificity: AA 500-750

Sequence: EIVTLNYLEP RTEYELCVQL VRRGEGGEGH PGPVRRFTTA SIGLPPPRGL NLLPKSQTTL NLTWQPIFPS SEDDFYVEVE RRSVQKSDQQ NIKVPGNLTS VLLNNLHPRE QYVVRARVNT KAQGEWSEDL TAWTLSDILP PQPENIKISN ITHSSAVISW TILDGYSISS ITIRYKVQGK NEDQHVDVKI KNATITQYQL KGLEPETAYQ VDIFAENNIG SSNPAFSHEL VTLPESQAPA DLGGGKMLLI A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 500-750 of human TEK (NP_000450.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-TEK antibody (ABIN6148993)

Huang, Han, Sun, Zhao, Liu, Yuan, Mao, Peng, Liu, Yin, He: "Kv1.3 channel blocker (ImKTx88) maintains blood-brain barrier in experimental autoimmune encephalomyelitis." in: Cell & bioscience, Vol. 7, pp. 31, (2017) (PubMed).

Chen, Ren, Zhang, Sun, Wang, Li, Zhang, Zhao: "Disorganized vascular structures in sporadic venous malformations: a possible correlation with balancing effect between Tie2 and TGF-β." in: Scientific reports, Vol. 4, pp. 5457, (2016) (PubMed).

Target Details for TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Alternative Name: TEK

Background: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.,TEK,CD202B,GLC3E,TIE-2,TIE2,VMCM,VMCM1,Tie2,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,Immunology & Inflammation,CD markers,Stem Cells,Endothelial Progenitors,Cardiovascular,Cardiovascular Markers,Endothelial Cells,Angiogenesis,TEK

Molecular Weight: 109 kDa/121 kDa/125 kDa

Gene ID: 7010

UniProt: Q02763

Pathways: RTK Signaling, Growth Factor Binding