Thimet Oligopeptidase 1 antibody (AA 1-260)

Catalog No. ABIN6149125

This Rabbit Polyclonal antibody specifically detects Thimet Oligopeptidase 1 in WB. It exhibits reactivity toward Human.

Quick Overview for Thimet Oligopeptidase 1 antibody (AA 1-260) (ABIN6149125)

Target: Thimet Oligopeptidase 1 (THOP1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thimet Oligopeptidase 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Thimet Oligopeptidase 1 Antibody

Binding Specificity: AA 1-260

Sequence: MKPPAACAGD MADAASPCSV VNDLRWDLSA QQIEERTREL IEQTKRVYDQ VGTQEFEDVS YESTLKALAD VEVTYTVQRN ILDFPQHVSP SKDIRTASTE ADKKLSEFDV EMSMREDVYQ RIVWLQEKVQ KDSLRPEAAR YLERLIKLGR RNGLHLPRET QENIKRIKKK LSLLCIDFNK NLNEDTTFLP FTLQELGGLP EDFLNSLEKM EDGKLKVTLK YPHYFPLLKK CHVPETRRKV EEAFNCRCKE ENCAILKELV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THOP1 (NP_003240.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Thimet Oligopeptidase 1

Target: Thimet Oligopeptidase 1 (THOP1)

Alternative Name: THOP1

Background: The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides.,THOP1,EP24.15,MEPD_HUMAN,MP78,TOP,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,THOP1

Molecular Weight: 28 kDa/78 kDa

Gene ID: 7064

UniProt: P52888