FGFR1 antibody (C-Term)

Catalog No. ABIN614919

The Goat Polyclonal anti-FGFR1 antibody (ABIN614919) specifically detects FGFR1 in WB, IHC (p) and EIA. The antibody is reactive with Human, Cow and Dog samples.

Quick Overview for FGFR1 antibody (C-Term) (ABIN614919)

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reactivity: Human, Cow, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This FGFR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-FGFR1 Antibody

Binding Specificity: C-Term

Sequence: CLPRHPAQLA NGGLKR

Specificity: This antibody detects CD331 / FGFR1 (C-term).

Cross-Reactivity (Details): Species reactivity (expected):Cow, DogSpecies reactivity (tested):Human

Purification: Immunoaffinity chromatography

Immunogen: Synthetic peptide from C-term of human FGFR1 Genename: FGFR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline buffer, pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Alternative Name: FGFR1

Background: The fibroblast growth factor receptor 1 belongs to the FGF Receptor subfamily. The full-length protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Ligand binding results in the activation of a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Various isoforms of FGFR1 have been identified that differ in structure and specificity. Defects in FGFR1 cause craniofacial abnormalities in diseases such as Pfeiffer syndrome and Jackson-Weiss syndrome.Synonyms: BFGFR, Basic fibroblast growth factor receptor 1, CEK, FGFBR, FLG, FLT-2, FLT2, Fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, HBGFR, N-sam, Proto-oncogene c-Fgr, bFGF-R-1

Gene ID: 2260

NCBI Accession: NP_056934

UniProt: P11362

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins