TXNRD2 antibody (AA 100-310)

Catalog No. ABIN6149741

This Rabbit Polyclonal antibody specifically detects TXNRD2 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for TXNRD2 antibody (AA 100-310) (ABIN6149741)

Target: TXNRD2 (Thioredoxin Reductase 2 (TXNRD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TXNRD2 Antibody

Binding Specificity: AA 100-310

Sequence: AALLGGLIQD APNYGWEVAQ PVPHDWRKMA EAVQNHVKSL NWGHRVQLQD RKVKYFNIKA SFVDEHTVCG VAKGGKEILL SADHIIIATG GRPRYPTHIE GALEYGITSD DIFWLKESPG KTLVVGASYV ALECAGFLTG IGLDTTIMMR SIPLRGFDQQ MSSMVIEHMA SHGTRFLRGC APSRVRRLPD GQLQVTWEDS TTGKEDTGTF D

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-310 of human Thioredoxin reductase 2 (Thioredoxin reductase 2 (TXNRD2 ) ) (NP_006431.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TXNRD2

Target: TXNRD2 (Thioredoxin Reductase 2 (TXNRD2))

Alternative Name: TXNRD2

Background: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.,TXNRD2,SELZ,TR,TR-BETA,TR3,TRXR2,Cell Biology & Developmental Biology,Endocrine & Metabolism,TXNRD2

Molecular Weight: 30 kDa/46 kDa/53 kDa/56 kDa

Gene ID: 10587

UniProt: Q9NNW7

Pathways: Cell RedoxHomeostasis