TXNRD2 antibody (AA 440-520)

Catalog No. ABIN7217394

The Rabbit Polyclonal anti-TXNRD2 antibody is suitable to detect TXNRD2 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for TXNRD2 antibody (AA 440-520) (ABIN7217394)

Target: TXNRD2 (Thioredoxin Reductase 2 (TXNRD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-TXNRD2 Antibody

Binding Specificity: AA 440-520

Purpose: Rabbit Anti-TrxR2 Polyclonal Antibody

Specificity: TrxR2 Polyclonal Antibody detects endogenous levels of TrxR2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human TrxR2 at AA range: 440-520

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TXNRD2

Target: TXNRD2 (Thioredoxin Reductase 2 (TXNRD2))

Alternative Name: TrxR2

Background: TXNRD2, KIAA1652, TRXR2, Thioredoxin reductase 2, mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin reductase TR3TXNRD2 encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The thioredoxin reductase 2 mitochondrial is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight: 56kD

Gene ID: 10587

UniProt: Q9NNW7

Pathways: Cell RedoxHomeostasis