Growth Hormone 1 antibody (Ser235)

Catalog No. ABIN615529

This Rabbit Polyclonal antibody specifically detects Growth Hormone 1 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Growth Hormone 1 antibody (Ser235) (ABIN615529)

Target: Growth Hormone 1 (GH1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Growth Hormone 1 Antibody

Binding Specificity: Ser235

Sequence: P-K-SP-P-S

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Immunoaffinity Chromatography

Immunogen: Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of serine 235

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-glycine, pH 7, 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C. Dilute only prior to immediate use.

Target Details for Growth Hormone 1

Target: Growth Hormone 1 (GH1)

Alternative Name: Somatotropin / Growth Hormone / GH1

Background: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.Synonyms: Growth hormone 1, HGH, Pituitary growth hormone

Gene ID: 2688

NCBI Accession: NP_000506

UniProt: P01241

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process