Liver Arginase antibody (AA 1-145)

Catalog No. ABIN615799

This Rabbit Polyclonal antibody specifically detects Liver Arginase in WB and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for Liver Arginase antibody (AA 1-145) (ABIN615799)

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Liver Arginase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Liver Arginase Antibody

Binding Specificity: AA 1-145

Specificity: This antibody recognizes Arginase I.

Cross-Reactivity (Details): Species reactivity (expected):Mouse (85 %), Rat (83 %), Rabbit (90 %), Bovine (89 %), Pig (90 %).
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 145 of Human Arginase-1. Genename: ARG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.1 M Tris-glycine, pH 7.0, 0.01 % Thimerosal, 10 % Glycerol

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for Liver Arginase

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Alternative Name: Arginase-1

Background: Arginase-1 (ARG1) catalyzes the hydrolysis of L-arginine into ornithine and urea, a critical step for the urea cycle. Defects in ARG1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia. There are several isoforms of mammalian arginase. The type I isoform, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Hepatocellular carcinoma usually shows higher protein expression of ARG1 than normal liver cells.Synonyms: ARG1, Liver-type arginase, Type I arginase

Gene ID: 383

NCBI Accession: NP_000036

UniProt: P05089

Pathways: Cellular Response to Molecule of Bacterial Origin