BIRC3 antibody

Catalog No. ABIN615850

This Rabbit Polyclonal antibody specifically detects BIRC3 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for BIRC3 antibody (ABIN615850)

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BIRC3 Antibody

Specificity: This antibody reacts to Baculoviral IAP Repeat-containing 3 (BIRC3). Predicted cross-reactivity based on amino acid sequence homology: bovine (84 %).

Purification: Immunoaffinity Chromatography

Immunogen: Recombinant Human cIAP2. Genename: BIRC3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.1 M Tris-glycine, pH 7.0 containing 10 % Glycerol and 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for BIRC3

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Alternative Name: IAP1 / BIRC3

Background: Apoptosis inhibitor 2 (API2) is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. API2 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. The names of API1 and API2 have been confusing. Suffice it to say that 'apoptosis inhibitor 2' is hiap-1 (inhibitor of apoptosis 1).Synonyms: API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing protein 3, C-IAP2, HIAP-1, IAP homolog C, Inhibitor of apoptosis protein 1, MIHC, RING finger protein 49, RNF49, TNFR2-TRAF-signaling complex protein 1, cIAP2

Gene ID: 330

NCBI Accession: NP_001156

UniProt: Q13489

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades