Fibrillarin antibody

Catalog No. ABIN3021515

This anti-Fibrillarin antibody is a Rabbit Polyclonal antibody detecting Fibrillarin in WB and IHC. Suitable for Human, Rat and Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for Fibrillarin antibody (ABIN3021515)

Target: Fibrillarin (FBL)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibrillarin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Fibrillarin Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human FBL

Isotype: IgG

Application Details

Application Notes: Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C/-80 °C

References for anti-Fibrillarin antibody (ABIN3021515)

Zheng, Xiong, Wu, Chen, Chen, Fleming, Gao, Bi, Ge: "Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells." in: Molecular & cellular proteomics : MCP, Vol. 14, Issue 6, pp. 1447-63, (2015) (PubMed).

Target Details for Fibrillarin

Target: Fibrillarin (FBL)

Alternative Name: FBL

Background: Fibrillarin is a 2-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place. Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2-O-ribose methylation of targeted nucleotides within the rRNA sequence. The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development.
Synonyms: FBL, FIB, FLRN, RNU3IP1

Gene ID: 2091

UniProt: P22087

Pathways: Ribonucleoside Biosynthetic Process