DcR2 antibody (AA 1-210) (APC)

Catalog No. ABIN6240814

The APC-conjugated Mouse Monoclonal anti-DcR2 antibody (Clone TRAIL-R4-01) (ABIN6240814) specifically detects DcR2 in FACS. The antibody is reactive with Human samples.

Quick Overview for DcR2 antibody (AA 1-210) (APC) (ABIN6240814)

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DcR2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: TRAIL-R4-01

Product Details anti-DcR2 Antibody (APC)

Binding Specificity: AA 1-210

Purpose: Anti-Hu CD264 APC

Cross-Reactivity (Details): Human

Characteristics: The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: TRAIL-R4 (aa 1-210) - hIgGhc fusion protein

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze,Protect from prolonged exposure to light

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for DcR2

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Alternative Name: CD264

Background: TNF receptor superfamily member 10d,TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).,TNFRSF10D, DcR2, TRUNDD, TRAILR4

Gene ID: 8793

UniProt: Q9UBN6

Pathways: Apoptosis