H2AFX antibody (pSer139)

Catalog No. ABIN6241012

This anti-H2AFX antibody is a Mouse Monoclonal antibody detecting H2AFX in WB and ICC. Suitable for Human and Mouse.

Quick Overview for H2AFX antibody (pSer139) (ABIN6241012)

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This H2AFX antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-H2AFX Antibody

Binding Specificity: pSer139

Immunogen: Recombinant Protein

Application Details

Application Notes: WB: 1:2000. ICC: 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for H2AFX

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Alternative Name: Histone H2A.X

Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.

UniProt: P16104

Pathways: Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus