Tec Protein Tyrosine Kinase (TEC) (AA 254-288) antibody

Catalog No. ABIN6242484

The Rabbit Polyclonal anti-Tec Protein Tyrosine Kinase antibody is suitable to detect Tec Protein Tyrosine Kinase in samples from Human. It has been validated for WB.

Quick Overview for Tec Protein Tyrosine Kinase (TEC) (AA 254-288) antibody (ABIN6242484)

Target: Tec Protein Tyrosine Kinase (TEC)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Clone: RB51015

Product Details

Binding Specificity: AA 254-288

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TEC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 254-288 amino acids from the Central region of human TEC.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details

Target: Tec Protein Tyrosine Kinase (TEC)

Alternative Name: TEC

Background: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.

Molecular Weight: 73581

UniProt: P42680

Pathways: Fc-epsilon Receptor Signaling Pathway