Tec Protein Tyrosine Kinase (TEC) antibody

Catalog No. ABIN969434

There are 4+ publications for this product available. The Mouse Monoclonal anti-Tec Protein Tyrosine Kinase antibody is suitable to detect Tec Protein Tyrosine Kinase in samples from Human. It has been validated for ELISA.

Quick Overview for Tec Protein Tyrosine Kinase (TEC) antibody (ABIN969434)

Target: Tec Protein Tyrosine Kinase (TEC)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA

Clone: 3A5

Product Details

Purpose: TEC Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of TEC expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References

Jolkver, Emer, Ballan, Krämer, Eikmanns, Marin: "Identification and characterization of a bacterial transport system for the uptake of pyruvate, propionate, and acetate in Corynebacterium glutamicum." in: Journal of bacteriology, Vol. 191, Issue 3, pp. 940-8, (2009) (PubMed).

van Dijk, van Den Akker, Amelsvoort, Mano, Löwenberg, von Lindern: "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells." in: Blood, Vol. 96, Issue 10, pp. 3406-13, (2000) (PubMed).

Tsai, Chow, Chen, Huang, Hong, Jan, Kuo, Tsao, Chen, Cheng: "Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing." in: The Journal of biological chemistry, Vol. 274, Issue 14, pp. 9455-62, (1999) (PubMed).

Kitanaka, Mano, Conley, Campana: "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells." in: Blood, Vol. 91, Issue 3, pp. 940-8, (1998) (PubMed).

Target Details

Target: Tec Protein Tyrosine Kinase (TEC)

Alternative Name: TEC

Background: TEC, it belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.

Molecular Weight: 74 kDa

UniProt: P42680

Pathways: Fc-epsilon Receptor Signaling Pathway