DAXX antibody (AA 473-502)

Catalog No. ABIN6243150

The Rabbit Polyclonal anti-DAXX antibody is suitable to detect DAXX in samples from Human. It has been validated for WB.

Quick Overview for DAXX antibody (AA 473-502) (ABIN6243150)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAXX antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB6869

Product Details anti-DAXX Antibody

Binding Specificity: AA 473-502

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DAXX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-502 amino acids from human DAXX.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Alternative Name: DAXX

Background: DAXX is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, this protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, this protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination.

Molecular Weight: 81373

NCBI Accession: NP_001135441, NP_001241646, NP_001341

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway